At the Winnett Specialist Group, we understand that weight management is a complex journey, and for many people, finding the right approach can be overwhelming. With over 23 years of experience as a surgeon, I have dedicated my career to helping patients navigate their weight loss options – whether through medication, lifestyle changes, or surgical interventions. In this blog, we’ll explore the role of weight loss medications, how they work, and who they may be suitable for.
The Rise of Weight Loss Medications
Over the past few years, weight loss medications have gained significant attention, often accompanied by both enthusiasm and misinformation. As a result, it is crucial to understand how these medications work, their effectiveness, and their potential risks. Unlike fad diets or quick fixes, these treatments are backed by scientific research and are designed to support long-term weight management.
How Do Weight Loss Medications Work?
Most weight loss medications function by targeting the brain’s appetite centres to reduce hunger and cravings. Some medications also help boost metabolic rate, making it easier for the body to burn kilojoules. Depending on a patient’s needs and medical history, different medications may be recommended.
Currently, there are seven main types of weight loss medications, categorised into three oral medications and four injectable treatments:
- Oral medications: Duromine, Topamax, and Contrave have been available for decades and continue to be effective for many patients.
- Injectable treatments: Saxenda, Ozempic & Wegovy (semaglutide), and Mounjaro are newer options that have shown promising results, particularly for patients with weight-related health conditions such as type 2 diabetes.
Who Can Benefit from Weight Loss Medications?
One of the most common questions I receive is, “Am I a good candidate for weight loss medications?” The answer varies based on individual health factors, but generally, we categorise patients based on their Body Mass Index (BMI):
- BMI 20-25 (Normal weight): Medications are usually not necessary.
- BMI 25-30 (Overweight): Medications may be considered, especially if other weight loss methods have not been successful.
- BMI 30+ (‘Obese’): Medications are often recommended as part of a comprehensive weight management plan, potentially in combination with other treatments.
Additionally, for some patients with a high BMI who are considering surgery, medications may be used as a pre-surgical tool to help reduce weight and improve surgical outcomes.
Where is the evidence these drugs work for weight loss?
The potency of Semaglutide was first confirmed in 2021 in The New England Journal of Medicine resulting in 14.9% weight loss compared to2.4% placebo in 1961 subjects over 68 weeks. A third of Semaglutide group patients lost 20% of weight.
Furthermore, 84% of patients with pre-diabetes returned to normoglycemia, compared with 47.8% in placebo. Weight circumference in the Semaglutide group was -13.4cm, compared with -2.4cm in placebo.
The dosing in the study was slightly higher than the dosage used in Australia and was 2.4mg weekly (Wegovy ®) compared with 1mg weekly (Ozempic). The two drugs are essentially the same ingredient – and just have different dosages.
The reason why semaglutide has constantly been in shortage globally is because it is a very effective short-term weight loss solution. It also helps keep blood sugar under control for patients with diabetes.
The Importance of Health Over Numbers
Weight loss is not just about hitting a certain number on the scale – it’s about improving overall health. Many patients see significant health benefits from modest weight loss, including a reduction or complete reversal of weight-related conditions such as diabetes, hypertension, and sleep apnoea.
A 2024, New England Journal of Medicine study, found that the risk of a primary heart or kidney event was 24% lower in the Semaglutide group. This study followed 3533 participants with Type II diabetes for 3.4 years.
In 2025 new evidence also shows that Semaglutide may lower the risk of alcoholism and quell the desire to drink alcohol, as reported in New Scientist Magazine.
All these benefits suggest that weight loss medications can be very effective with careful oversight and monitoring. Our goal at the Winnett Specialist Group is to help patients feel better, live healthier, and regain confidence – not just achieve a specific weight.
Are these treatments safe?
A common concern is the safety of weight loss medications. Injectable treatments like Saxenda, Wegovy, and Ozempic are GLP-1 analogs, meaning they mimic natural hormones in the body that regulate hunger and insulin response. These medications are considered safe for most patients, but as with any treatment, there are certain contraindications. That’s why professional medical guidance is essential.
The Challenge of Medication Access
Due to their rising popularity, some weight loss medications have been difficult to obtain. While compounding pharmacies have attempted to fill this gap, we strongly advise only using medications from reputable, approved sources to ensure safety and effectiveness.
Finding the Right Approach for You
At the Winnett Specialist Group, we take a personalised approach to weight management. Whether through dietetic support, Very Low-Calorie Diets (VLCDs), medications, or surgical procedures (such as gastric balloons, bands, sleeves, or bypasses), we work closely with our patients to create a plan that suits their needs.
There is no one-size-fits-all solution when it comes to weight loss. The most important step is taking the first step – seeking professional guidance and discussing your options.
Your Journey Starts Here
We understand that making the decision to seek help can be daunting. But you are not alone. Our team is here to guide you with compassion, expertise, and judgment-free support. If you’re ready to explore your options, schedule a consultation with us today.
Together, we can find the right path toward a healthier, happier you.
Understanding Weight Loss Medications: A Guide for Patients
Mr Jason Winnett
Laparoscopic and Bariatric Surgeon
P (03) 9417 1555 admin@winnettspecialistgroup.com.au
www.winnettspecialistgroup.com.au
Queens Terrace, 382 Victoria Parade, East Melbourne 3002
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